MDMA Assisted Therapy Guide

What is MDMA?
MDMA is a small organic compound known as a monoamine alkaloid, structurally and chemically related to amphetamines.

What Does MDMA Do to My Brain (Pharmacology)?
MDMA (3,4-methylenedioxymethamphetamine) is a small organic compound known as a monoamine alkaloid, related chemically to amphetamine, that stimulates the brain to release neurotransmitters and hormones.

Neurotransmitters released: serotonin, dopamine, and norepinephrine. Hormones released: oxytocin, vasopressin, cortisol, and prolactin.

What is MDMA-Assisted Therapy?
MDMA-assisted therapy involves ‘talk-therapy’ alongside the ingestion of MDMA. Researchers and clinicians often describe three distinct therapy phases: preparation, the acute MDMA experience, and integration. The non-psychedelic elements of this approach are essential for both effectiveness and safety.

MDMA-Assisted Therapy Positive Effects!
MDMA smooths communication, makes things look less threatening and fearful, nurturing people’s ability to experience each other in a more positive way. As Mithoefer notes, “It makes sense then that MDMA could make it easier to communicate if people weren’t as sensitive to interpreting someone else’s expression as being threatening.”

Negative Effects of MDMA!
MDMA is a potent substance. Negative effects can occur during the MDMA experience and in the days and weeks following.

The physiological effects of MDMA include reduced or lack of appetite, sleep disturbances, hyperthermia, increased blood pressure, tachycardia, nystagmus (eye wobble, blurred vision), mydriasis (dilated pupils), panic attack, anxiety, confusion, nausea, vomiting, muscle tension, tremors, shaking, sweating, blurred vision, teeth grinding, jaw tightness and clenching, moderate potential for addiction or problematic use in non-medical settings, dizziness, dry mouth, thirst, difficulty concentrating, restlessness, feeling cold, and restless legs.

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